ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Psmb8

Full Name:

proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)

Alias:

Lmp7|MGC124945|Ring10

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

20p12

Physical Location:

4786263-4789161 on NC_005119.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5696 Symbol (Name): PSMB8 (proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7))

Ortholog Status:

The human GeneID 5696 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Psmb8
Fold Change:		-1.33
P Value:		0.002
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_080767.1	NP_542945.1	NC_005119.2 range: 4786263..4789161, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005839	proteasome core complex	Cellular Component	TAS (1451788)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	IEA
GO:0005839	proteasome core complex	Cellular Component	IEA
GO:0004298	threonine endopeptidase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA
GO:0006955	immune response	Biological Process	IEA
GO:0019882	antigen processing and presentation	Biological Process	IEA
GO:0019882	antigen processing and presentation	Biological Process	ISS
GO:0019882	antigen processing and presentation	Biological Process	NAS (1451788)