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Gene Information
Gene ID:25033
Full Name:somatostatin receptor 1
Organism:Rattus norvegicus (Rat)
Genetic Location:6q23
Physical Location:78803392-78806977 on NC_005105.2
Gene Type:protein-coding
Human Ortholog:GeneID: 6751    Symbol (Name): SSTR1 (somatostatin receptor 1)
Ortholog Status:The human GeneID 6751 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Sstr1
Fold Change:-1.24
P Value:0.001
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012719.1NP_036851.1NC_005105.2 range: 78803392..78806977
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005624membrane fractionCellular ComponentISS
GO:0016021integral to membraneCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentISS
GO:0001584rhodopsin-like receptor activityMolecular FunctionIEA
GO:0004994somatostatin receptor activityMolecular FunctionISS
GO:0004994somatostatin receptor activityMolecular FunctionIMP (1400442)
GO:0004994somatostatin receptor activityMolecular FunctionIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0007218neuropeptide signaling pathwayBiological ProcessISS
GO:0007215glutamate signaling pathwayBiological ProcessISS
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessISS
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIEA
GO:0007165signal transductionBiological ProcessIEA
GO:0030217T cell differentiationBiological ProcessNAS (8932524)
Other Database Cross Links
NCBI Entrez Gene:25033