ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Camk4

Full Name:

calcium/calmodulin-dependent protein kinase IV

Alias:

Ccdpk|RATCCDPK

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

18p12

Physical Location:

25408042-25626392 on NC_005117.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 814 Symbol (Name): CAMK4 (calcium/calmodulin-dependent protein kinase IV)

Ortholog Status:

The human GeneID 814 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Camk4
Fold Change:		-1.38
P Value:		0
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Camk4
Fold Change:		-1.23
P Value:		0.002
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Gene Information

Original ID1:		Camk4
Fold Change:		-1.32
P Value:		0.001
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012727.3	NP_036859.2	NC_005117.2 range: 25408042..25626392

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0004683	calmodulin-dependent protein kinase activity	Molecular Function	IDA (2538431)
GO:0016563	transcription activator activity	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0006468	protein amino acid phosphorylation	Biological Process	IDA (2538431)
GO:0006913	nucleocytoplasmic transport	Biological Process	ISS
GO:0007165	signal transduction	Biological Process	ISS
GO:0007270	nerve-nerve synaptic transmission	Biological Process	ISS
GO:0006468	protein amino acid phosphorylation	Biological Process	ISS