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Gene Information
Gene ID:25054
Full Name:neurotrophic tyrosine kinase, receptor, type 2
Organism:Rattus norvegicus (Rat)
Genetic Location:17p14
Physical Location:11494462-11811653 on NC_005116.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 4915    Symbol (Name): NTRK2 (neurotrophic tyrosine kinase, receptor, type 2)
Ortholog Status:The human GeneID 4915 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Ntrk2
Fold Change:1.51
P Value:0
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012731.1NP_036863.1NC_005116.2 range: 11494462..11811653, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0060076excitatory synapseCellular ComponentIDA (17079678)
GO:0048786presynaptic active zoneCellular ComponentIDA (16477614)
GO:0043195terminal buttonCellular ComponentISS
GO:0043025cell somaCellular ComponentIDA (17079678)
GO:0030426growth coneCellular ComponentIDA (17079678)
GO:0030425dendriteCellular ComponentIDA (17079678)
GO:0030424axonCellular ComponentIDA (17079678)
GO:0014069postsynaptic densityCellular ComponentIDA (16477614)
GO:0009986cell surfaceCellular ComponentIDA (17079678)
GO:0005829cytosolCellular ComponentISS
GO:0005886plasma membraneCellular ComponentISS
GO:0005886plasma membraneCellular ComponentIDA (17079678)
GO:0005030neurotrophin receptor activityMolecular FunctionIDA (16477614)
GO:0048403brain-derived neurotrophic factor bindingMolecular FunctionIDA (16477614)
GO:0048403brain-derived neurotrophic factor bindingMolecular FunctionIMP (16983663)
GO:0004714transmembrane receptor protein tyrosine kinase activityMolecular FunctionIMP (17447135)
GO:0005515protein bindingMolecular FunctionISS
GO:0005030neurotrophin receptor activityMolecular FunctionIMP (16983663)
GO:0016301kinase activityMolecular FunctionIEA
GO:0050773regulation of dendrite developmentBiological ProcessIMP (15654844)
GO:0051968positive regulation of synaptic transmission, glutamatergicBiological ProcessIMP (16983663)
GO:0046928regulation of neurotransmitter secretionBiological ProcessIDA (16477614)
GO:0046777protein amino acid autophosphorylationBiological ProcessIMP (17447135)
GO:0046548retinal rod cell developmentBiological ProcessISS
GO:0007631feeding behaviorBiological ProcessISS
GO:0042490mechanoreceptor differentiationBiological ProcessISS
GO:0031547brain-derived neurotrophic factor receptor signaling pathwayBiological ProcessIMP (15654844)
GO:0019222regulation of metabolic processBiological ProcessISS
GO:0014047glutamate secretionBiological ProcessISS
GO:0001570vasculogenesisBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:25054