ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hk1

Full Name:

hexokinase 1

Alias:

HEXOKIN|RATHEXOKIN

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

20q11

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3098 Symbol (Name): HK1 (hexokinase 1)

Ortholog Status:

The human GeneID 3098 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hk1
Fold Change:		-1.22
P Value:		0.006
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005901	caveola	Cellular Component	IDA (16419038)
GO:0005829	cytosol	Cellular Component	ISS
GO:0005739	mitochondrion	Cellular Component	ISS
GO:0005739	mitochondrion	Cellular Component	IDA (15574336)
GO:0016887	ATPase activity	Molecular Function	IC (15574336)
GO:0004340	glucokinase activity	Molecular Function	IDA (15574336)
GO:0005536	glucose binding	Molecular Function	IDA (15574336)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IC (15574336)
GO:0005515	protein binding	Molecular Function	IPI (16419038)
GO:0004672	protein kinase activity	Molecular Function	IDA (7531990)
GO:0004396	hexokinase activity	Molecular Function	ISS
GO:0004396	hexokinase activity	Molecular Function	IDA (15138155)
GO:0018108	peptidyl-tyrosine phosphorylation	Biological Process	IDA (7531990)
GO:0043066	negative regulation of apoptosis	Biological Process	IMP (15574336)
GO:0046777	protein amino acid autophosphorylation	Biological Process	IDA (2059200\|7531990)
GO:0018107	peptidyl-threonine phosphorylation	Biological Process	IDA (7531990)
GO:0018105	peptidyl-serine phosphorylation	Biological Process	IDA (7531990)
GO:0006468	protein amino acid phosphorylation	Biological Process	IDA (2059200)
GO:0006096	glycolysis	Biological Process	IEA
GO:0006096	glycolysis	Biological Process	IDA (15574336)
GO:0046835	carbohydrate phosphorylation	Biological Process	IDA (15574336)