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Gene Information
Gene ID:25116
Full Name:hydroxysteroid 11-beta dehydrogenase 1
Organism:Rattus norvegicus (Rat)
Genetic Location:13q27
Physical Location:109063490-109089467 on NC_005112.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 3290    Symbol (Name): HSD11B1 (hydroxysteroid (11-beta) dehydrogenase 1)
Ortholog Status:The human GeneID 3290 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hsd11b1
Fold Change:1.17
P Value:0.004
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_017080.2NP_058776.2NC_005112.2 range: 109063490..109089467, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0045177apical part of cellCellular ComponentIDA (12810566)
GO:0031965nuclear membraneCellular ComponentIDA (11250946)
GO:0005792microsomeCellular ComponentIDA (16234247)
GO:0005737cytoplasmCellular ComponentIDA (12810566)
GO:0005791rough endoplasmic reticulumCellular ComponentIDA (11250946)
GO:0003723RNA bindingMolecular FunctionIEA
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0016491oxidoreductase activityMolecular FunctionIDA (11751610)
GO:0050661NADP bindingMolecular FunctionIDA (15761036)
GO:0005496steroid bindingMolecular FunctionIPI (15761036)
GO:000384511-beta-hydroxysteroid dehydrogenase activityMolecular FunctionIDA (2808402)
GO:000384511-beta-hydroxysteroid dehydrogenase activityMolecular FunctionIMP (16188378)
GO:000384511-beta-hydroxysteroid dehydrogenase activityMolecular FunctionISS
GO:0003964RNA-directed DNA polymerase activityMolecular FunctionIEA
GO:0005488bindingMolecular FunctionIEA
GO:0008152metabolic processBiological ProcessIEA
GO:0008152metabolic processBiological ProcessIDA (11751610)
GO:0006713glucocorticoid catabolic processBiological ProcessIDA (12460758)
GO:0030324lung developmentBiological ProcessISS
GO:0043456regulation of pentose-phosphate shuntBiological ProcessIDA (16234247)
GO:0006278RNA-dependent DNA replicationBiological ProcessIEA
GO:0006704glucocorticoid biosynthetic processBiological ProcessIDA (12460758)
Other Database Cross Links
NCBI Entrez Gene:25116