ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hsd11b1

Full Name:

hydroxysteroid 11-beta dehydrogenase 1

Alias:

LRRGT00065

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

13q27

Physical Location:

109063490-109089467 on NC_005112.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3290 Symbol (Name): HSD11B1 (hydroxysteroid (11-beta) dehydrogenase 1)

Ortholog Status:

The human GeneID 3290 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hsd11b1
Fold Change:		1.17
P Value:		0.004
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017080.2	NP_058776.2	NC_005112.2 range: 109063490..109089467, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0045177	apical part of cell	Cellular Component	IDA (12810566)
GO:0031965	nuclear membrane	Cellular Component	IDA (11250946)
GO:0005792	microsome	Cellular Component	IDA (16234247)
GO:0005737	cytoplasm	Cellular Component	IDA (12810566)
GO:0005791	rough endoplasmic reticulum	Cellular Component	IDA (11250946)
GO:0003723	RNA binding	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IDA (11751610)
GO:0050661	NADP binding	Molecular Function	IDA (15761036)
GO:0005496	steroid binding	Molecular Function	IPI (15761036)
GO:0003845	11-beta-hydroxysteroid dehydrogenase activity	Molecular Function	IDA (2808402)
GO:0003845	11-beta-hydroxysteroid dehydrogenase activity	Molecular Function	IMP (16188378)
GO:0003845	11-beta-hydroxysteroid dehydrogenase activity	Molecular Function	ISS
GO:0003964	RNA-directed DNA polymerase activity	Molecular Function	IEA
GO:0005488	binding	Molecular Function	IEA
GO:0008152	metabolic process	Biological Process	IEA
GO:0008152	metabolic process	Biological Process	IDA (11751610)
GO:0006713	glucocorticoid catabolic process	Biological Process	IDA (12460758)
GO:0030324	lung development	Biological Process	ISS
GO:0043456	regulation of pentose-phosphate shunt	Biological Process	IDA (16234247)
GO:0006278	RNA-dependent DNA replication	Biological Process	IEA
GO:0006704	glucocorticoid biosynthetic process	Biological Process	IDA (12460758)