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Gene Information
Gene ID:25151
Symbol:Igf2r
Full Name:insulin-like growth factor 2 receptor
Organism:Rattus norvegicus (Rat)
Chromosome:1
Genetic Location:1q11
Physical Location:42253272-42341645 on NC_005100.2
Gene Type:protein-coding
Human Ortholog:GeneID: 3482    Symbol (Name): IGF2R (insulin-like growth factor 2 receptor)
Ortholog Status:The human GeneID 3482 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Igf2r
Fold Change:-1.14
P Value:0.004
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Gene Information
Original ID1:Igf2r
Fold Change:-1.19
P Value:0.005
Note:Differential expression between ethanol and water groups in amygdala
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012756.1NP_036888.1NC_005100.2 range: 42253272..42341645
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005641nuclear envelope lumenCellular ComponentISS
GO:0005634nucleusCellular ComponentISS
GO:0005624membrane fractionCellular ComponentISS
GO:0005624membrane fractionCellular ComponentIDA (16407557)
GO:0005768endosomeCellular ComponentISS
GO:0016020membraneCellular ComponentISS
GO:0016021integral to membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentTAS (12596253)
GO:0030140trans-Golgi network transport vesicleCellular ComponentISS
GO:0005737cytoplasmCellular ComponentIEA
GO:0019899enzyme bindingMolecular FunctionIDA (11247783)
GO:0031995insulin-like growth factor II bindingMolecular FunctionIDA (16407557)
GO:0001948glycoprotein bindingMolecular FunctionISS
GO:0001965G-protein alpha-subunit bindingMolecular FunctionIDA (16407557)
GO:0004872receptor activityMolecular FunctionIEA
GO:0005010insulin-like growth factor receptor activityMolecular FunctionTAS (12596253)
GO:0005215transporter activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0005520insulin-like growth factor bindingMolecular FunctionISS
GO:0005537mannose bindingMolecular FunctionISS
GO:0015031protein transportBiological ProcessTAS (12596253)
GO:0006810transportBiological ProcessIEA
GO:0042981regulation of apoptosisBiological ProcessIMP (16825605)
Other Database Cross Links
NCBI Entrez Gene:25151
RGD:2871
Ensembl:ENSRNOG00000014997
dbSNP:Igf2r