ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Igf2r

Full Name:

insulin-like growth factor 2 receptor

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q11

Physical Location:

42253272-42341645 on NC_005100.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3482 Symbol (Name): IGF2R (insulin-like growth factor 2 receptor)

Ortholog Status:

The human GeneID 3482 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Igf2r
Fold Change:		-1.14
P Value:		0.004
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Gene Information

Original ID1:		Igf2r
Fold Change:		-1.19
P Value:		0.005
Note:		Differential expression between ethanol and water groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012756.1	NP_036888.1	NC_005100.2 range: 42253272..42341645

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005641	nuclear envelope lumen	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	ISS
GO:0005624	membrane fraction	Cellular Component	ISS
GO:0005624	membrane fraction	Cellular Component	IDA (16407557)
GO:0005768	endosome	Cellular Component	ISS
GO:0016020	membrane	Cellular Component	ISS
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	TAS (12596253)
GO:0030140	trans-Golgi network transport vesicle	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0019899	enzyme binding	Molecular Function	IDA (11247783)
GO:0031995	insulin-like growth factor II binding	Molecular Function	IDA (16407557)
GO:0001948	glycoprotein binding	Molecular Function	ISS
GO:0001965	G-protein alpha-subunit binding	Molecular Function	IDA (16407557)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005010	insulin-like growth factor receptor activity	Molecular Function	TAS (12596253)
GO:0005215	transporter activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0005520	insulin-like growth factor binding	Molecular Function	ISS
GO:0005537	mannose binding	Molecular Function	ISS
GO:0015031	protein transport	Biological Process	TAS (12596253)
GO:0006810	transport	Biological Process	IEA
GO:0042981	regulation of apoptosis	Biological Process	IMP (16825605)