ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pcsk1

Full Name:

proprotein convertase subtilisin/kexin type 1

Alias:

BDP|PC1|PC3

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

2q11-q12

Physical Location:

1923308-1970237 on NC_005101.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5122 Symbol (Name): PCSK1 (proprotein convertase subtilisin/kexin type 1)

Ortholog Status:

The human GeneID 5122 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pcsk1
Fold Change:		-1.12
P Value:		0.002
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017091.2	NP_058787.1	NC_005101.2 range: 1923308..1970237

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA
GO:0030141	secretory granule	Cellular Component	IDA (10806118)
GO:0005615	extracellular space	Cellular Component	ISS
GO:0004285	proprotein convertase 1 activity	Molecular Function	IEA
GO:0043559	insulin binding	Molecular Function	IPI (10806118)
GO:0008233	peptidase activity	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0004289	subtilase activity	Molecular Function	IEA
GO:0004285	proprotein convertase 1 activity	Molecular Function	IMP (16497799)
GO:0051087	chaperone binding	Molecular Function	IPI (10806118)
GO:0006508	proteolysis	Biological Process	IMP (16497799)
GO:0006508	proteolysis	Biological Process	IEA
GO:0016486	peptide hormone processing	Biological Process	IMP (16497799)
GO:0016486	peptide hormone processing	Biological Process	ISS
GO:0043043	peptide biosynthetic process	Biological Process	ISS