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Gene Information
Gene ID:25205
Full Name:interleukin 6 signal transducer
Organism:Rattus norvegicus (Rat)
Genetic Location:2q14-q16
Physical Location:43806300-43842363 on NC_005101.2
Gene Type:protein-coding
Human Ortholog:GeneID: 3572    Symbol (Name): IL6ST (interleukin 6 signal transducer (gp130, oncostatin M receptor))
Ortholog Status:The human GeneID 3572 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:25205
Fold Change:1.915
P Value:0.015
Note:Fold change is average ratio of AA to ANA.
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001008725.2NP_001008725.1NC_005101.2 range: 43806300..43842363
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0005575cellular_componentCellular ComponentND
GO:0005125cytokine activityMolecular FunctionTAS (12538632)
GO:0005515protein bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0004921interleukin-11 receptor activityMolecular FunctionISS
GO:0019970interleukin-11 bindingMolecular FunctionISS
GO:0004896hematopoietin/interferon-class (D200-domain) cytokine receptor activityMolecular FunctionIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0008593regulation of Notch signaling pathwayBiological ProcessISS
GO:0014911positive regulation of smooth muscle cell migrationBiological ProcessIMP (17322172)
GO:0019221cytokine and chemokine mediated signaling pathwayBiological ProcessISS
GO:0030307positive regulation of cell growthBiological ProcessTAS (12538632)
GO:0046883regulation of hormone secretionBiological ProcessTAS (12538632)
GO:0008593regulation of Notch signaling pathwayBiological ProcessIEA
GO:0008284positive regulation of cell proliferationBiological ProcessISS
GO:0005977glycogen metabolic processBiological ProcessIEA
GO:0005977glycogen metabolic processBiological ProcessISS
GO:0006642triacylglycerol mobilizationBiological ProcessIMP (8843746)
GO:0007165signal transductionBiological ProcessIEA
GO:0007165signal transductionBiological ProcessISS
GO:0007259JAK-STAT cascadeBiological ProcessIMP (17385713)
GO:0007584response to nutrientBiological ProcessIEP (15371280)
GO:0008284positive regulation of cell proliferationBiological ProcessIEA
GO:0051481reduction of cytosolic calcium ion concentrationBiological ProcessIMP (17437036)
Other Database Cross Links
NCBI Entrez Gene:25205