ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Tyro3

Full Name:

TYRO3 protein tyrosine kinase 3

Alias:

Brt

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

3q36.1

Physical Location:

106309670-106328606 on NC_005102.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7301 Symbol (Name): TYRO3 (TYRO3 protein tyrosine kinase)

Ortholog Status:

The human GeneID 7301 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		25232
Fold Change:		2.206
P Value:		<0.001
Note:		Fold change is average ratio of AA to ANA.

Dataset Information

Name:		15846778
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:		DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017092.1	NP_058788.1	NC_005102.2 range: 106309670..106328606

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0043548	phosphoinositide 3-kinase binding	Molecular Function	IPI (10627473)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IDA (10627473)
GO:0007155	cell adhesion	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA