ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Akt2

Full Name:

thymoma viral proto-oncogene 2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q22

Physical Location:

82686232-82726543 on NC_005100.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 208 Symbol (Name): AKT2 (v-akt murine thymoma viral oncogene homolog 2)

Ortholog Status:

The human GeneID 208 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.87066
Original ID2:		Akt2
Fold Change:		1.23
P Value:		0.00932
Note:		Lower levels in the hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017093.1	NP_058789.1	NC_005100.2 range: 82686232..82726543

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	IDA (16445997)
GO:0030027	lamellipodium	Cellular Component	ISS
GO:0005829	cytosol	Cellular Component	IDA (16445997)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0004674	protein serine/threonine kinase activity	Molecular Function	TAS (12089343)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA (16445997)
GO:0006468	protein amino acid phosphorylation	Biological Process	IDA (16445997)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	TAS (12089343)
GO:0046328	regulation of JNK cascade	Biological Process	ISS