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Gene Information
Gene ID:25244
Symbol:Bckdha
Full Name:branched chain ketoacid dehydrogenase E1, alpha polypeptide
Alias:BCKDA|E1a
Organism:Rattus norvegicus (Rat)
Chromosome:1
Genetic Location:1q21
Physical Location:80837905-80866671 on NC_005100.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 593    Symbol (Name): BCKDHA (branched chain keto acid dehydrogenase E1, alpha polypeptide)
Ortholog Status:The human GeneID 593 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Bckdha
Fold Change:1.14
P Value:0.01
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Gene Information
Original ID1:Bckdha
Fold Change:-1.17
P Value:0.007
Note:Differential expression between ethanol and saccharin groups in amygdala
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012782.1NP_036914.1NC_005100.2 range: 80837905..80866671, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005759mitochondrial matrixCellular ComponentIEA
GO:0005739mitochondrionCellular ComponentTAS (2822716)
GO:0005739mitochondrionCellular ComponentISS
GO:0005739mitochondrionCellular ComponentIEA
GO:0005575cellular_componentCellular ComponentND
GO:0005947mitochondrial alpha-ketoglutarate dehydrogenase complexCellular ComponentISS
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0016536cyclin-dependent protein kinase 5 activator regulator activityMolecular FunctionIEA
GO:0016536cyclin-dependent protein kinase 5 activator regulator activityMolecular FunctionISS
GO:0030955potassium ion bindingMolecular FunctionIEA
GO:00471012-oxoisovalerate dehydrogenase (acylating) activityMolecular FunctionTAS (2822716)
GO:0003674molecular_functionMolecular FunctionND
GO:0005515protein bindingMolecular FunctionIEA
GO:00038633-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activityMolecular FunctionIEA
GO:0003826alpha-ketoacid dehydrogenase activityMolecular FunctionTAS (2822716)
GO:0003826alpha-ketoacid dehydrogenase activityMolecular FunctionISS
GO:0032403protein complex bindingMolecular FunctionIPI (3619032)
GO:0051384response to glucocorticoid stimulusBiological ProcessIEP (8034710)
GO:0045893positive regulation of transcription, DNA-dependentBiological ProcessISS
GO:0045893positive regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0009083branched chain family amino acid catabolic processBiological ProcessTAS (2822716)
GO:0009083branched chain family amino acid catabolic processBiological ProcessISS
GO:0008152metabolic processBiological ProcessIEA
GO:0007584response to nutrientBiological ProcessIEP (8109974)
GO:0051591response to cAMPBiological ProcessIEP (8034710)
Other Database Cross Links
NCBI Entrez Gene:25244
RGD:2196
Ensembl:ENSRNOG00000020607
dbSNP:Bckdha