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Gene Information
Gene ID:25252
Symbol:Dlgh1
Full Name:discs, large homolog 1 (Drosophila)
Alias:Dlg1|SAP97
Organism:Rattus norvegicus (Rat)
Chromosome:11
Genetic Location:11q22
Physical Location:70735282-70930372 on NC_005110.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 1739    Symbol (Name): DLG1 (discs, large homolog 1 (Drosophila))
Ortholog Status:The human GeneID 1739 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Dlgh1
Fold Change:1.28
P Value:0
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012788.1NP_036920.1NC_005110.2 range: 70735282..70930372, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0009925basal plasma membraneCellular ComponentIDA (7891172)
GO:0042734presynaptic membraneCellular ComponentIDA (7891172)
GO:0016323basolateral plasma membraneCellular ComponentISS
GO:0014069postsynaptic densityCellular ComponentTAS
GO:0030054cell junctionCellular ComponentIEA
GO:0045202synapseCellular ComponentIEA
GO:0030315T-tubuleCellular ComponentIDA (11181181)
GO:0045211postsynaptic membraneCellular ComponentIEA
GO:0045211postsynaptic membraneCellular ComponentTAS (12933808)
GO:0005886plasma membraneCellular ComponentISS
GO:0005789endoplasmic reticulum membraneCellular ComponentIEA
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0030165PDZ domain bindingMolecular FunctionIPI (15024025)
GO:0035256metabotropic glutatmate receptor bindingMolecular FunctionIMP
GO:0019902phosphatase bindingMolecular FunctionISS
GO:0019901protein kinase bindingMolecular FunctionISS
GO:0008022protein C-terminus bindingMolecular FunctionISS
GO:0008022protein C-terminus bindingMolecular FunctionIPI (11181181)
GO:0005515protein bindingMolecular FunctionISS
GO:0035255ionotropic glutamate receptor bindingMolecular FunctionIPI (12933808|16540568)
GO:0042391regulation of membrane potentialBiological ProcessISS
GO:0030866cortical actin cytoskeleton organization and biogenesisBiological ProcessISS
GO:0001935endothelial cell proliferationBiological ProcessISS
GO:0016337cell-cell adhesionBiological ProcessISS
GO:0008104protein localizationBiological ProcessISS
GO:0007155cell adhesionBiological ProcessIEP (7891172)
GO:0007015actin filament organizationBiological ProcessISS
GO:0045930negative regulation of mitotic cell cycleBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:25252
RGD:2505
Ensembl:ENSRNOG00000038597
dbSNP:Dlgh1