ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Id1

Full Name:

inhibitor of DNA binding 1

Alias:

ID125A|Idb1|MGC156482

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

3q41

Physical Location:

143086161-143087288 on NC_005102.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3397 Symbol (Name): ID1 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein)

Ortholog Status:

The human GeneID 3397 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.2113
Original ID2:		Id1
Fold Change:		1.27
P Value:		0.00809
Note:		Lower levels in the hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012797.2	NP_036929.2	NC_005102.2 range: 143086161..143087288

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005515	protein binding	Molecular Function	ISS
GO:0016564	transcription repressor activity	Molecular Function	ISS
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	ISS
GO:0007507	heart development	Biological Process	ISS
GO:0016481	negative regulation of transcription	Biological Process	ISS
GO:0030509	BMP signaling pathway	Biological Process	ISS
GO:0043433	negative regulation of transcription factor activity	Biological Process	ISS
GO:0045765	regulation of angiogenesis	Biological Process	ISS