ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Mfge8

Full Name:

milk fat globule-EGF factor 8 protein

Alias:

AGS|MFGME8|MFGMP-E8|OAcGD3S

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q31

Physical Location:

134870033-134885392 on NC_005100.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4240 Symbol (Name): MFGE8 (milk fat globule-EGF factor 8 protein)

Ortholog Status:

The human GeneID 4240 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Mfge8
Fold Change:		1.15
P Value:		0.005
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012811.2	NP_036943.1	NC_005100.2 range: 134870033..134885392, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005615	extracellular space	Cellular Component	ISS
GO:0019897	extrinsic to plasma membrane	Cellular Component	ISS
GO:0016020	membrane	Cellular Component	IEA
GO:0009897	external side of plasma membrane	Cellular Component	ISS
GO:0001786	phosphatidylserine binding	Molecular Function	ISS
GO:0005178	integrin binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IEA
GO:0008429	phosphatidylethanolamine binding	Molecular Function	ISS
GO:0043627	response to estrogen stimulus	Biological Process	IEP (12801995)
GO:0008284	positive regulation of cell proliferation	Biological Process	IEP (11085522)
GO:0007338	single fertilization	Biological Process	IEA
GO:0007155	cell adhesion	Biological Process	IEA
GO:0006911	phagocytosis, engulfment	Biological Process	ISS
GO:0006910	phagocytosis, recognition	Biological Process	ISS
GO:0050766	positive regulation of phagocytosis	Biological Process	ISS