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Gene Information
Gene ID:25293
Full Name:aquaporin 4
Organism:Rattus norvegicus (Rat)
Genetic Location:18p13
Physical Location:6628190-6642699 on NC_005117.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 361    Symbol (Name): AQP4 (aquaporin 4)
Ortholog Status:The human GeneID 361 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:25293
Fold Change:0.52
P Value:0.0325
Note:Fold change is average ratio of AA to ANA.
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012825.2NP_036957.1NC_005117.2 range: 6628190..6642699, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005887integral to plasma membraneCellular ComponentIDA (12507761)
GO:0016020membraneCellular ComponentIDA (12507761)
GO:0015250water channel activityMolecular FunctionIDA (7528931|12507761)
GO:0015250water channel activityMolecular FunctionISS
GO:0015288porin activityMolecular FunctionIDA (12507761)
GO:0006833water transportBiological ProcessIDA (7528931)
Other Database Cross Links
NCBI Entrez Gene:25293