ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Myh8

Full Name:

myosin, heavy polypeptide 8, skeletal muscle, perinatal

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

10q24

Physical Location:

53973710-54002441 on NC_005109.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4626 Symbol (Name): MYH8 (myosin, heavy chain 8, skeletal muscle, perinatal)

Ortholog Status:

The human GeneID 4626 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Myh8
Fold Change:		-1.1
P Value:		0.01
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_001080186.1	XP_001080186.1	NC_005109.2 range: 53973710..54002441

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016459	myosin complex	Cellular Component	ISS
GO:0016459	myosin complex	Cellular Component	IEA
GO:0005863	striated muscle thick filament	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005575	cellular_component	Cellular Component	ND
GO:0005524	ATP binding	Molecular Function	IEA
GO:0003779	actin binding	Molecular Function	IEA
GO:0003774	motor activity	Molecular Function	IEA
GO:0003674	molecular_function	Molecular Function	ND
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0006941	striated muscle contraction	Biological Process	IEA
GO:0008150	biological_process	Biological Process	ND