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Gene Information
Gene ID:252942
Full Name:myosin, heavy polypeptide 8, skeletal muscle, perinatal
Organism:Rattus norvegicus (Rat)
Genetic Location:10q24
Physical Location:53973710-54002441 on NC_005109.2
Gene Type:protein-coding
Human Ortholog:GeneID: 4626    Symbol (Name): MYH8 (myosin, heavy chain 8, skeletal muscle, perinatal)
Ortholog Status:The human GeneID 4626 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Myh8
Fold Change:-1.1
P Value:0.01
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
XM_001080186.1XP_001080186.1NC_005109.2 range: 53973710..54002441
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016459myosin complexCellular ComponentISS
GO:0016459myosin complexCellular ComponentIEA
GO:0005863striated muscle thick filamentCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIEA
GO:0005575cellular_componentCellular ComponentND
GO:0005524ATP bindingMolecular FunctionIEA
GO:0003779actin bindingMolecular FunctionIEA
GO:0003774motor activityMolecular FunctionIEA
GO:0003674molecular_functionMolecular FunctionND
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0006941striated muscle contractionBiological ProcessIEA
GO:0008150biological_processBiological ProcessND
Other Database Cross Links
NCBI Entrez Gene:252942