ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cst3

Full Name:

cystatin C

Alias:

CYSC|MGC105556

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

3q41

Physical Location:

137650902-137654775 on NC_005102.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1471 Symbol (Name): CST3 (cystatin C)

Ortholog Status:

The human GeneID 1471 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Cst3
Fold Change:		1.14
P Value:		0.01
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012837.1	NP_036969.1	NC_005102.2 range: 137650902..137654775, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	IDA (2689174)
GO:0004869	cysteine protease inhibitor activity	Molecular Function	IEA
GO:0004869	cysteine protease inhibitor activity	Molecular Function	TAS (2689174\|16140167)
GO:0006979	response to oxidative stress	Biological Process	IMP (16140167)
GO:0043067	regulation of programmed cell death	Biological Process	IMP (16140167)