Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:25319
Full Name:ferritin heavy chain 1
Organism:Rattus norvegicus (Rat)
Genetic Location:1q43
Physical Location:212430450-212432740 on NC_005100.2
Gene Type:protein-coding
Human Ortholog:GeneID: 2495    Symbol (Name): FTH1 (ferritin, heavy polypeptide 1)
Ortholog Status:The human GeneID 2495 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rn.54447
Original ID2:Fth1
Fold Change:1.58
P Value:0
Note:higher levels in hippocampus of iP than iNP rats
Dataset Information
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).
Gene Information
Original ID1:Fth1
Fold Change:1.29
Dataset Information
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012848.1NP_036980.1NC_005100.2 range: 212430450..212432740
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005575cellular_componentCellular ComponentND
GO:0003674molecular_functionMolecular FunctionND
GO:0008199ferric iron bindingMolecular FunctionIEA
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005488bindingMolecular FunctionIEA
GO:0004322ferroxidase activityMolecular FunctionIEA
GO:0006826iron ion transportBiological ProcessIEA
GO:0006955immune responseBiological ProcessISS
GO:0008150biological_processBiological ProcessND
GO:0008285negative regulation of cell proliferationBiological ProcessISS
GO:0006879cellular iron ion homeostasisBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:25319