ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Fth1

Full Name:

ferritin heavy chain 1

Alias:

Fth

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q43

Physical Location:

212430450-212432740 on NC_005100.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2495 Symbol (Name): FTH1 (ferritin, heavy polypeptide 1)

Ortholog Status:

The human GeneID 2495 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.54447
Original ID2:		Fth1
Fold Change:		1.58
P Value:		0
Note:		higher levels in hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Information

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012848.1	NP_036980.1	NC_005100.2 range: 212430450..212432740

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0003674	molecular_function	Molecular Function	ND
GO:0008199	ferric iron binding	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0005488	binding	Molecular Function	IEA
GO:0004322	ferroxidase activity	Molecular Function	IEA
GO:0006826	iron ion transport	Biological Process	IEA
GO:0006955	immune response	Biological Process	ISS
GO:0008150	biological_process	Biological Process	ND
GO:0008285	negative regulation of cell proliferation	Biological Process	ISS
GO:0006879	cellular iron ion homeostasis	Biological Process	IEA