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Gene Information
Gene ID:25349
Full Name:sodium channel, voltage-gated, type II, beta
Organism:Rattus norvegicus (Rat)
Genetic Location:8q22
Physical Location:48068842-48078631 on NC_005107.2
Gene Type:protein-coding
Human Ortholog:GeneID: 6327    Symbol (Name): SCN2B (sodium channel, voltage-gated, type II, beta)
Ortholog Status:The human GeneID 6327 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Scn2b
Fold Change:-1.45
P Value:0.002
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012877.1NP_037009.1NC_005107.2 range: 48068842..48078631
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0001518voltage-gated sodium channel complexCellular ComponentTAS (8521473)
GO:0016020membraneCellular ComponentIEA
GO:0005216ion channel activityMolecular FunctionIEA
GO:0005248voltage-gated sodium channel activityMolecular FunctionIDA (8521473)
Other Database Cross Links
NCBI Entrez Gene:25349