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Gene Information
Gene ID:25399
Full Name:calcium channel, voltage-dependent, alpha2/delta subunit 1
Organism:Rattus norvegicus (Rat)
Genetic Location:4q11
Physical Location:15139880-15566739 on NC_005103.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 781    Symbol (Name): CACNA2D1 (calcium channel, voltage-dependent, alpha 2/delta subunit 1)
Ortholog Status:The human GeneID 781 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Cacna2d1
Fold Change:-1.29
P Value:0.002
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012919.2NP_037051.2NC_005103.2 range: 15139880..15566739, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005891voltage-gated calcium channel complexCellular ComponentISS
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0016529sarcoplasmic reticulumCellular ComponentISS
GO:0005891voltage-gated calcium channel complexCellular ComponentIMP (11604404)
GO:0030315T-tubuleCellular ComponentISS
GO:0005244voltage-gated ion channel activityMolecular FunctionIEA
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0005262calcium channel activityMolecular FunctionIEA
GO:0005245voltage-gated calcium channel activityMolecular FunctionIMP (11604404)
GO:0015270dihydropyridine-sensitive calcium channel activityMolecular FunctionISS
GO:0006816calcium ion transportBiological ProcessTAS (12606261)
GO:0006816calcium ion transportBiological ProcessISS
GO:0006816calcium ion transportBiological ProcessIEA
GO:0006811ion transportBiological ProcessIEA
GO:0051924regulation of calcium ion transportBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:25399