| Gene Information |
| Gene ID: | | 25403 |
| Symbol: | | Cast |
| Full Name: | | calpastatin |
| Alias: | | MGC108997 |
| Organism: | | Rattus norvegicus (Rat) |
| Chromosome: | | 2 |
| Genetic Location: | | 2q11 |
| Physical Location: | | 1495047-1608476 on NC_005101.2, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 831 Symbol (Name): CAST (calpastatin) |
| Ortholog Status: | | The human GeneID 831 is also in human dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Cast | | Fold Change: | | -1.16 | | P Value: | | 0.004 | | Note: | | Differential expression between ethanol and water groups in amygdala |
| | Dataset Information | | Name: | | 18405950 | | Method: | | Microarray | | Tissue: | | Nucleus accumbens and amygdala | | Phenotype: | | Ethanol self-administration, alcohol-preferring | | Publication: | | Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed | | Summary: | | The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0002020 | protease binding | Molecular Function | IC (17429681) | |
| GO:0030161 | calpain inhibitor activity | Molecular Function | IDA (17429681) | |
| GO:0030161 | calpain inhibitor activity | Molecular Function | IEA | |
| GO:0030161 | calpain inhibitor activity | Molecular Function | TAS (9475181) | |
| GO:0007520 | myoblast fusion | Biological Process | IEP (12832042) | |
| GO:0042176 | regulation of protein catabolic process | Biological Process | TAS (12832042) | |
| GO:0043086 | negative regulation of catalytic activity | Biological Process | IDA (17429681) | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 25403 |
| RGD: | | 2278 |
| Ensembl: | | ENSRNOG00000010286 |
| dbSNP: | | Cast |
