ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Col2a1

Full Name:

collagen, type II, alpha 1

Alias:

CG2A1A|COLLII

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

7q36

Physical Location:

136679218-136707975 on NC_005106.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1280 Symbol (Name): COL2A1 (collagen, type II, alpha 1)

Ortholog Status:

The human GeneID 1280 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Col2a1
Fold Change:		-1.13
P Value:		0.004
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012929.1	NP_037061.1	NC_005106.2 range: 136679218..136707975, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005615	extracellular space	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005585	collagen type II	Cellular Component	TAS (10652357)
GO:0005581	collagen	Cellular Component	IEA
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005201	extracellular matrix structural constituent	Molecular Function	TAS (10652357)
GO:0005201	extracellular matrix structural constituent	Molecular Function	IEA
GO:0030199	collagen fibril organization	Biological Process	ISS
GO:0006817	phosphate transport	Biological Process	IEA
GO:0006029	proteoglycan metabolic process	Biological Process	ISS
GO:0001502	cartilage condensation	Biological Process	ISS
GO:0051216	cartilage development	Biological Process	IEP (9822201)