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Gene Information
Gene ID:25451
Full Name:gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2
Organism:Rattus norvegicus (Rat)
Genetic Location:10q21
Physical Location:27602008-27819643 on NC_005109.2
Gene Type:protein-coding
Human Ortholog:GeneID: 2561    Symbol (Name): GABRB2 (gamma-aminobutyric acid (GABA) A receptor, beta 2)
Ortholog Status:The human GeneID 2561 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Gabrb2
Fold Change:-1.32
P Value:0.004
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Gabrb2
Fold Change:-1.32
P Value:0.004
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012957.2NP_037089.1NC_005109.2 range: 27602008..27819643
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0045211postsynaptic membraneCellular ComponentIEA
GO:0045202synapseCellular ComponentIEA
GO:0030054cell junctionCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentIEA
GO:0005237inhibitory extracellular ligand-gated ion channel activityMolecular FunctionIMP (11877425)
GO:0004890GABA-A receptor activityMolecular FunctionIMP (11877425)
GO:0031404chloride ion bindingMolecular FunctionIEA
GO:0030594neurotransmitter receptor activityMolecular FunctionIEA
GO:0004890GABA-A receptor activityMolecular FunctionTAS (11161482)
GO:0005216ion channel activityMolecular FunctionIEA
GO:0004890GABA-A receptor activityMolecular FunctionIEA
GO:0005230extracellular ligand-gated ion channel activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIPI
GO:0005254chloride channel activityMolecular FunctionIEA
GO:0006811ion transportBiological ProcessIEA
GO:0007214gamma-aminobutyric acid signaling pathwayBiological ProcessTAS (11877425)
Other Database Cross Links
NCBI Entrez Gene:25451