ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Il1rap

Full Name:

interleukin 1 receptor accessory protein

Alias:

IL-1RAcp|MGC114349

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

11q22

Physical Location:

76100008-76222494 on NC_005110.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3556 Symbol (Name): IL1RAP (interleukin 1 receptor accessory protein)

Ortholog Status:

The human GeneID 3556 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Il1rap
Fold Change:		-1.15
P Value:		0.009
Note:		Differential expression between ethanol and water groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012968.1	NP_037100.1	NC_005110.2 range: 76100008..76222494, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0004871	signal transducer activity	Molecular Function	ISS
GO:0004908	interleukin-1 receptor activity	Molecular Function	IEA
GO:0004908	interleukin-1 receptor activity	Molecular Function	ISS
GO:0005149	interleukin-1 receptor binding	Molecular Function	TAS (8964912)
GO:0005515	protein binding	Molecular Function	ISS
GO:0019966	interleukin-1 binding	Molecular Function	TAS (8964912)
GO:0030674	protein binding, bridging	Molecular Function	TAS (8964912)
GO:0019221	cytokine and chemokine mediated signaling pathway	Biological Process	ISS
GO:0042094	interleukin-2 biosynthetic process	Biological Process	ISS