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Gene Information
Gene ID:25466
Symbol:Il1rap
Full Name:interleukin 1 receptor accessory protein
Alias:IL-1RAcp|MGC114349
Organism:Rattus norvegicus (Rat)
Chromosome:11
Genetic Location:11q22
Physical Location:76100008-76222494 on NC_005110.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 3556    Symbol (Name): IL1RAP (interleukin 1 receptor accessory protein)
Ortholog Status:The human GeneID 3556 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Il1rap
Fold Change:-1.15
P Value:0.009
Note:Differential expression between ethanol and water groups in amygdala
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012968.1NP_037100.1NC_005110.2 range: 76100008..76222494, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0004871signal transducer activityMolecular FunctionISS
GO:0004908interleukin-1 receptor activityMolecular FunctionIEA
GO:0004908interleukin-1 receptor activityMolecular FunctionISS
GO:0005149interleukin-1 receptor bindingMolecular FunctionTAS (8964912)
GO:0005515protein bindingMolecular FunctionISS
GO:0019966interleukin-1 bindingMolecular FunctionTAS (8964912)
GO:0030674protein binding, bridgingMolecular FunctionTAS (8964912)
GO:0019221cytokine and chemokine mediated signaling pathwayBiological ProcessISS
GO:0042094interleukin-2 biosynthetic processBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:25466
RGD:2893
Ensembl:ENSRNOG00000001928
dbSNP:Il1rap