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Gene Information
Gene ID:25469
Full Name:potassium voltage-gated channel, shaker-related subfamily, member 4
Organism:Rattus norvegicus (Rat)
Genetic Location:3q33
Physical Location:92781794-92784920 on NC_005102.2
Gene Type:protein-coding
Human Ortholog:GeneID: 3739    Symbol (Name): KCNA4 (potassium voltage-gated channel, shaker-related subfamily, member 4)
Ortholog Status:The human GeneID 3739 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:25469
Fold Change:0.887
P Value:0.024
Note:Fold change is average ratio of AA to ANA.
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012971.2NP_037103.1NC_005102.2 range: 92781794..92784920
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005887integral to plasma membraneCellular ComponentIDA (10330244)
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0008076voltage-gated potassium channel complexCellular ComponentIEA
GO:0005216ion channel activityMolecular FunctionIDA (2384173)
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIPI
GO:0005267potassium channel activityMolecular FunctionIDA (2384173)
GO:0005249voltage-gated potassium channel activityMolecular FunctionIEA
GO:0005249voltage-gated potassium channel activityMolecular FunctionIDA (2384173)
GO:0005244voltage-gated ion channel activityMolecular FunctionIEA
GO:0030955potassium ion bindingMolecular FunctionIEA
GO:0006811ion transportBiological ProcessIEA
GO:0006813potassium ion transportBiological ProcessIEA
GO:0006813potassium ion transportBiological ProcessTAS (2384173)
Other Database Cross Links
NCBI Entrez Gene:25469