ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Kcna4

Full Name:

potassium voltage-gated channel, shaker-related subfamily, member 4

Alias:

KCHAN|Kv1.4|Kv4|RHK1|RK3

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

3q33

Physical Location:

92781794-92784920 on NC_005102.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3739 Symbol (Name): KCNA4 (potassium voltage-gated channel, shaker-related subfamily, member 4)

Ortholog Status:

The human GeneID 3739 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		25469
Fold Change:		0.887
P Value:		0.024
Note:		Fold change is average ratio of AA to ANA.

Dataset Information

Name:		15846778
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:		DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012971.2	NP_037103.1	NC_005102.2 range: 92781794..92784920

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005887	integral to plasma membrane	Cellular Component	IDA (10330244)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0008076	voltage-gated potassium channel complex	Cellular Component	IEA
GO:0005216	ion channel activity	Molecular Function	IDA (2384173)
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IPI
GO:0005267	potassium channel activity	Molecular Function	IDA (2384173)
GO:0005249	voltage-gated potassium channel activity	Molecular Function	IEA
GO:0005249	voltage-gated potassium channel activity	Molecular Function	IDA (2384173)
GO:0005244	voltage-gated ion channel activity	Molecular Function	IEA
GO:0030955	potassium ion binding	Molecular Function	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0006813	potassium ion transport	Biological Process	IEA
GO:0006813	potassium ion transport	Biological Process	TAS (2384173)