ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Nedd4

Full Name:

neural precursor cell expressed, developmentally down-regulated gene 4

Alias:

Nedd4a

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

8q24

Physical Location:

77267573-77337402 on NC_005107.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4734 Symbol (Name): NEDD4 (neural precursor cell expressed, developmentally down-regulated 4)

Ortholog Status:

The human GeneID 4734 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Nedd4a
Fold Change:		-1.17
P Value:		0.009
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Nedd4a
Fold Change:		-1.18
P Value:		0.006
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_343427.3	XP_343428.3	NC_005107.2 range: 77267573..77337402

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000151	ubiquitin ligase complex	Cellular Component	IEA
GO:0005902	microvillus	Cellular Component	IDA (9227416)
GO:0005829	cytosol	Cellular Component	ISS
GO:0005829	cytosol	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005622	intracellular	Cellular Component	IEA
GO:0045121	membrane raft	Cellular Component	IDA (11248052)
GO:0000151	ubiquitin ligase complex	Cellular Component	ISS
GO:0017080	sodium channel regulator activity	Molecular Function	IPI (8665844)
GO:0016874	ligase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	IEA
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IDA (11527431)
GO:0005515	protein binding	Molecular Function	IEA
GO:0006512	ubiquitin cycle	Biological Process	IEA
GO:0006955	immune response	Biological Process	IEP (11248052)
GO:0006464	protein modification process	Biological Process	IEA