Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:25489
Full Name:neural precursor cell expressed, developmentally down-regulated gene 4
Organism:Rattus norvegicus (Rat)
Genetic Location:8q24
Physical Location:77267573-77337402 on NC_005107.2
Gene Type:protein-coding
Human Ortholog:GeneID: 4734    Symbol (Name): NEDD4 (neural precursor cell expressed, developmentally down-regulated 4)
Ortholog Status:The human GeneID 4734 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Nedd4a
Fold Change:-1.17
P Value:0.009
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Nedd4a
Fold Change:-1.18
P Value:0.006
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
XM_343427.3XP_343428.3NC_005107.2 range: 77267573..77337402
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000151ubiquitin ligase complexCellular ComponentIEA
GO:0005902microvillusCellular ComponentIDA (9227416)
GO:0005829cytosolCellular ComponentISS
GO:0005829cytosolCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIEA
GO:0005622intracellularCellular ComponentIEA
GO:0045121membrane raftCellular ComponentIDA (11248052)
GO:0000151ubiquitin ligase complexCellular ComponentISS
GO:0017080sodium channel regulator activityMolecular FunctionIPI (8665844)
GO:0016874ligase activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0004842ubiquitin-protein ligase activityMolecular FunctionIEA
GO:0004842ubiquitin-protein ligase activityMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIDA (11527431)
GO:0005515protein bindingMolecular FunctionIEA
GO:0006512ubiquitin cycleBiological ProcessIEA
GO:0006955immune responseBiological ProcessIEP (11248052)
GO:0006464protein modification processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:25489