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Gene Information
Gene ID:2551
Symbol:GABPA
Full Name:GA binding protein transcription factor, alpha subunit 60kDa
Alias:E4TF1-60|E4TF1A|NFT2|NRF2|NRF2A
Organism:Homo sapiens (Human)
Chromosome:21
Genetic Location:21q21-q22.1|21q21.3
Physical Location:26029569-26066212 on NC_000021.7
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.473470
Note:"Class II, down-regulated gene"
Dataset Information
Name:16292326
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_002040.3NP_002031.2NC_000021.7 range: 26029569..26066212
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentTAS (9016666)
GO:0003700transcription factor activityMolecular FunctionTAS (7590737|8441384)
GO:0003702RNA polymerase II transcription factor activityMolecular FunctionTAS (8441384)
GO:0003713transcription coactivator activityMolecular FunctionTAS (8441384)
GO:0005515protein bindingMolecular FunctionIPI (10675337)
GO:0043565sequence-specific DNA bindingMolecular FunctionIEA
GO:0006350transcriptionBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0006366transcription from RNA polymerase II promoterBiological ProcessTAS (8441384)
Other Database Cross Links
NCBI Entrez Gene:2551
HGNC:4071
Ensembl:ENSG00000154727
MIM:600609
HPRD:11793
HuGE Navigator:2551
dbSNP:GABPA
GeneCard:GABPA
AceView:GABPA