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Gene Information
Gene ID:25516
Full Name:prepronociceptin
Organism:Rattus norvegicus (Rat)
Genetic Location:15p12
Physical Location:44822634-44835636 on NC_005114.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 5368    Symbol (Name): PNOC (prepronociceptin)
Ortholog Status:The human GeneID 5368 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Pnoc
Fold Change:1.23
P Value:0.008
Note:Differential expression between ethanol and saccharin groups in amygdala
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_013007.1NP_037139.1NC_005114.2 range: 44822634..44835636, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentIEA
GO:0001515opioid peptide activityMolecular FunctionIEA
GO:0007218neuropeptide signaling pathwayBiological ProcessIDA (11826101)
GO:0007218neuropeptide signaling pathwayBiological ProcessIEA
GO:0007268synaptic transmissionBiological ProcessIDA (11826101)
GO:0007268synaptic transmissionBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:25516