| Gene Information |
| Gene ID: | | 25516 |
| Symbol: | | Pnoc |
| Full Name: | | prepronociceptin |
| Alias: | | N23K|Npnc1 |
| Organism: | | Rattus norvegicus (Rat) |
| Chromosome: | | 15 |
| Genetic Location: | | 15p12 |
| Physical Location: | | 44822634-44835636 on NC_005114.2, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 5368 Symbol (Name): PNOC (prepronociceptin) |
| Ortholog Status: | | The human GeneID 5368 is also in human dataset(s). |
|
| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Pnoc | | Fold Change: | | 1.23 | | P Value: | | 0.008 | | Note: | | Differential expression between ethanol and saccharin groups in amygdala |
| | Dataset Information | | Name: | | 18405950 | | Method: | | Microarray | | Tissue: | | Nucleus accumbens and amygdala | | Phenotype: | | Ethanol self-administration, alcohol-preferring | | Publication: | | Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed | | Summary: | | The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group. |
|
|
| Gene Refseq Sequence Annotation |
|
| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005576 | extracellular region | Cellular Component | IEA | |
| GO:0001515 | opioid peptide activity | Molecular Function | IEA | |
| GO:0007218 | neuropeptide signaling pathway | Biological Process | IDA (11826101) | |
| GO:0007218 | neuropeptide signaling pathway | Biological Process | IEA | |
| GO:0007268 | synaptic transmission | Biological Process | IDA (11826101) | |
| GO:0007268 | synaptic transmission | Biological Process | IEA | |
|
| Other Database Cross Links |
| NCBI Entrez Gene: | | 25516 |
| RGD: | | 3362 |
| Ensembl: | | ENSRNOG00000014231 |
| dbSNP: | | Pnoc |
