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Gene Information
Gene ID:25520
Symbol:Prkag1
Full Name:protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Alias:Prkaac|Prkga1
Organism:Rattus norvegicus (Rat)
Chromosome:7
Genetic Location:7q36
Physical Location:137582340-137599761 on NC_005106.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 5571    Symbol (Name): PRKAG1 (protein kinase, AMP-activated, gamma 1 non-catalytic subunit)
Ortholog Status:The human GeneID 5571 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rn.11089
Original ID2:Prkag1
Fold Change:1.26
P Value:0.00136
Note:Lower levels in the hippocampus of iP than iNP rats
Dataset Information
Name:15660665
Method:Microarray
Tissue:Hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).
Gene Information
Original ID1:Prkag1
Fold Change:-1.19
Tissue:Caudate-putamen
Dataset Information
Name:17517326
Method:Microarray
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_013010.2NP_037142.1NC_005106.2 range: 137582340..137599761, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0043234protein complexCellular ComponentIDA (14511394)
GO:0031588AMP-activated protein kinase complexCellular ComponentIMP (10698692)
GO:0005634nucleusCellular ComponentIEA
GO:0005634nucleusCellular ComponentISS
GO:0031588AMP-activated protein kinase complexCellular ComponentIDA (16648175)
GO:0004679AMP-activated protein kinase activityMolecular FunctionIDA (14511394|16648175)
GO:0019901protein kinase bindingMolecular FunctionIPI (16648175)
GO:0016208AMP bindingMolecular FunctionIMP (10698692)
GO:0016208AMP bindingMolecular FunctionIDA (16648175)
GO:0004679AMP-activated protein kinase activityMolecular FunctionTAS (8626596)
GO:0004679AMP-activated protein kinase activityMolecular FunctionIMP (10698692)
GO:0006950response to stressBiological ProcessTAS (8626596)
GO:0006633fatty acid biosynthetic processBiological ProcessIEA
GO:0050790regulation of catalytic activityBiological ProcessIDA (16648175)
GO:0051291protein heterooligomerizationBiological ProcessIDA (14511394)
Other Database Cross Links
NCBI Entrez Gene:25520
RGD:3388
Ensembl:ENSRNOG00000014813
dbSNP:Prkag1