ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Slc2a3

Full Name:

solute carrier family 2 (facilitated glucose transporter), member 3

Alias:

GLUT3

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q42

Physical Location:

159210008-159221250 on NC_005103.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6515 Symbol (Name): SLC2A3 (solute carrier family 2 (facilitated glucose transporter), member 3)

Ortholog Status:

The human GeneID 6515 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Slc2a3
Fold Change:		-1.2
P Value:		0.007
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Slc2a3
Fold Change:		-1.22
P Value:		0.005
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017102.2	NP_058798.2	NC_005103.2 range: 159210008..159221250, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0030672	synaptic vesicle membrane	Cellular Component	IDA (10318820)
GO:0005901	caveola	Cellular Component	IDA (16419038)
GO:0005886	plasma membrane	Cellular Component	IDA (9275091\|15320870)
GO:0005737	cytoplasm	Cellular Component	IDA (9004533)
GO:0005215	transporter activity	Molecular Function	IEA
GO:0016936	galactoside binding	Molecular Function	IDA (8645164)
GO:0019900	kinase binding	Molecular Function	IPI (16419038)
GO:0033222	xylose binding	Molecular Function	IDA (8645164)
GO:0055056	D-glucose transmembrane transporter activity	Molecular Function	IDA (15320870)
GO:0015145	monosaccharide transmembrane transporter activity	Molecular Function	IDA (8645164)
GO:0005351	sugar:hydrogen symporter activity	Molecular Function	IEA
GO:0005355	glucose transmembrane transporter activity	Molecular Function	IEA
GO:0005355	glucose transmembrane transporter activity	Molecular Function	TAS (11738800)
GO:0005515	protein binding	Molecular Function	IPI (16419038)
GO:0005536	glucose binding	Molecular Function	IDA (8645164)
GO:0008643	carbohydrate transport	Biological Process	IEA
GO:0015758	glucose transport	Biological Process	TAS (11738800)
GO:0043066	negative regulation of apoptosis	Biological Process	IDA (15320870)
GO:0046323	glucose import	Biological Process	IDA (15320870)
GO:0015749	monosaccharide transport	Biological Process	IDA (8645164)