ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Stxbp1

Full Name:

syntaxin binding protein 1

Alias:

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

3p11

Physical Location:

11762104-11825530 on NC_005102.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6812 Symbol (Name): STXBP1 (syntaxin binding protein 1)

Ortholog Status:

The human GeneID 6812 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		25558
Fold Change:		1.8
P Value:		<0.001
Note:		Fold change is average ratio of AA to ANA.

Dataset Information

Name:		15846778
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:		DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013038.3	NP_037170.1	NC_005102.2 range: 11762104..11825530, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	ISS
GO:0005829	cytosol	Cellular Component	TAS (12093152)
GO:0005886	plasma membrane	Cellular Component	IDA (12093152)
GO:0005515	protein binding	Molecular Function	IDA (12963086)
GO:0019905	syntaxin binding	Molecular Function	IDA (12506202)
GO:0017075	syntaxin-1 binding	Molecular Function	IDA (12093152)
GO:0047485	protein N-terminus binding	Molecular Function	IPI (8247129)
GO:0005515	protein binding	Molecular Function	ISS
GO:0007412	axon target recognition	Biological Process	ISS
GO:0016188	synaptic vesicle maturation	Biological Process	ISS
GO:0006944	membrane fusion	Biological Process	IPI (12506202)