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Gene Information
Gene ID:25565
Symbol:Tle4
Full Name:transducin-like enhancer of split 4, homolog of Drosophila E(spl)
Alias:Esp2
Organism:Rattus norvegicus (Rat)
Chromosome:1
Genetic Location:1q43
Physical Location:217636134-217770593 on NC_005100.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 7091    Symbol (Name): TLE4 (transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila))
Ortholog Status:The human GeneID 7091 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Tle4
Fold Change:1.14
P Value:0.009
Note:Differential expression between ethanol and saccharin groups in amygdala
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_019141.1NP_062014.1NC_005100.2 range: 217636134..217770593, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIDA (8245004)
GO:0005634nucleusCellular ComponentIEA
GO:0003682chromatin bindingMolecular FunctionISS
GO:0003705RNA polymerase II transcription factor activity, enhancer bindingMolecular FunctionISS
GO:0003714transcription corepressor activityMolecular FunctionISS
GO:0003714transcription corepressor activityMolecular FunctionNAS (8245004)
GO:0005515protein bindingMolecular FunctionISS
GO:0016055Wnt receptor signaling pathwayBiological ProcessISS
GO:0016055Wnt receptor signaling pathwayBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessISS
GO:0016481negative regulation of transcriptionBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:25565
RGD:3868
Ensembl:ENSRNOG00000013239
dbSNP:Tle4