ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Tle4

Full Name:

transducin-like enhancer of split 4, homolog of Drosophila E(spl)

Alias:

Esp2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q43

Physical Location:

217636134-217770593 on NC_005100.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7091 Symbol (Name): TLE4 (transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila))

Ortholog Status:

The human GeneID 7091 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Tle4
Fold Change:		1.14
P Value:		0.009
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_019141.1	NP_062014.1	NC_005100.2 range: 217636134..217770593, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (8245004)
GO:0005634	nucleus	Cellular Component	IEA
GO:0003682	chromatin binding	Molecular Function	ISS
GO:0003705	RNA polymerase II transcription factor activity, enhancer binding	Molecular Function	ISS
GO:0003714	transcription corepressor activity	Molecular Function	ISS
GO:0003714	transcription corepressor activity	Molecular Function	NAS (8245004)
GO:0005515	protein binding	Molecular Function	ISS
GO:0016055	Wnt receptor signaling pathway	Biological Process	ISS
GO:0016055	Wnt receptor signaling pathway	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	ISS
GO:0016481	negative regulation of transcription	Biological Process	ISS