ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Fn1

Full Name:

fibronectin 1

Alias:

FIBNEC|fn-1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

9q33

Physical Location:

70702180-70771154 on NC_005108.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2335 Symbol (Name): FN1 (fibronectin 1)

Ortholog Status:

The human GeneID 2335 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Gene Information

Gene Information

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_019143.2	NP_062016.2	NC_005108.2 range: 70702180..70771154, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016324	apical plasma membrane	Cellular Component	ISS
GO:0005793	ER-Golgi intermediate compartment	Cellular Component	ISS
GO:0005604	basement membrane	Cellular Component	IDA (14656002)
GO:0005578	proteinaceous extracellular matrix	Cellular Component	TAS (11768240)
GO:0005578	proteinaceous extracellular matrix	Cellular Component	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0005201	extracellular matrix structural constituent	Molecular Function	TAS (17065553)
GO:0016504	protease activator activity	Molecular Function	ISS
GO:0045340	mercury ion binding	Molecular Function	IDA (11768240)
GO:0042060	wound healing	Biological Process	ISS
GO:0030198	extracellular matrix organization and biogenesis	Biological Process	IMP (12388756)
GO:0007160	cell-matrix adhesion	Biological Process	ISS
GO:0007160	cell-matrix adhesion	Biological Process	IMP (12388756)
GO:0007155	cell adhesion	Biological Process	ISS
GO:0007044	cell-substrate junction assembly	Biological Process	ISS
GO:0006916	anti-apoptosis	Biological Process	IMP (15677310)
GO:0001503	ossification	Biological Process	TAS (15833739)