ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

FN1

Full Name:

fibronectin 1

Alias:

CIG|DKFZp686F10164|DKFZp686H0342|DKFZp686I1370|DKFZp686O13149|ED-B|FINC|FN|FNZ|GFND2|LETS|MSF

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q34

Physical Location:

215933421-216009035 on NC_000002.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 14268 Rat: 25661 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

AW385690

Dataset Information

Name:		12065639
Method:		Microarray
Tissue:		Frontal and motor cortices
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:		We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S117

195326948

Region:		195326948-216757195
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0031093	platelet alpha granule lumen	Cellular Component	EXP (444675)
GO:0005576	extracellular region	Cellular Component	EXP (444675)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005576	extracellular region	Cellular Component	NAS (14718574)
GO:0005578	proteinaceous extracellular matrix	Cellular Component	NAS
GO:0005793	ER-Golgi intermediate compartment	Cellular Component	IDA (15308636)
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0008201	heparin binding	Molecular Function	NAS (10075919)
GO:0005201	extracellular matrix structural constituent	Molecular Function	NAS
GO:0005518	collagen binding	Molecular Function	NAS (3024962)
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	NAS (15609325)
GO:0008152	metabolic process	Biological Process	IEA
GO:0006953	acute-phase response	Biological Process	IEA
GO:0009611	response to wounding	Biological Process	NAS (7989369)
GO:0016477	cell migration	Biological Process	NAS
GO:0007155	cell adhesion	Biological Process	NAS (1423622)