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Gene Information
Gene ID:25702
Symbol:Pnlip
Full Name:pancreatic lipase
Alias:PANLI
Organism:Rattus norvegicus (Rat)
Chromosome:1
Genetic Location:1q55
Physical Location:265107811-265120968 on NC_005100.2
Gene Type:protein-coding
Human Ortholog:GeneID: 5406    Symbol (Name): PNLIP (pancreatic lipase)
Ortholog Status:The human GeneID 5406 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Pnlip
Fold Change:1.18
P Value:0.001
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_013161.1NP_037293.1NC_005100.2 range: 265107811..265120968
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005575cellular_componentCellular ComponentND
GO:0005576extracellular regionCellular ComponentIEA
GO:0004806triacylglycerol lipase activityMolecular FunctionIEA
GO:0016298lipase activityMolecular FunctionIDA (8203536|15181189)
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0006629lipid metabolic processBiological ProcessIDA (15181189)
GO:0016042lipid catabolic processBiological ProcessIEA
GO:0030299cholesterol absorptionBiological ProcessIEA
GO:0030299cholesterol absorptionBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:25702
RGD:3360
Ensembl:ENSRNOG00000017725
dbSNP:Pnlip