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Gene Information
Gene ID:25742
Full Name:S100 protein, beta polypeptide, neural
Organism:Rattus norvegicus (Rat)
Genetic Location:20p12
Physical Location:12791439-12824507 on NC_005119.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 6285    Symbol (Name): S100B (S100 calcium binding protein B)
Ortholog Status:The human GeneID 6285 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:S100b
Fold Change:1.14
P Value:0.008
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:S100b
Fold Change:1.14
P Value:0.008
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_013191.1NP_037323.1NC_005119.2 range: 12791439..12824507, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0001726ruffleCellular ComponentISS
GO:0005634nucleusCellular ComponentIEA
GO:0005634nucleusCellular ComponentISS
GO:0005737cytoplasmCellular ComponentISS
GO:0043025cell somaCellular ComponentISS
GO:0043025cell somaCellular ComponentIEA
GO:0048156tau protein bindingMolecular FunctionISS
GO:0048154S100 beta bindingMolecular FunctionISS
GO:0042803protein homodimerization activityMolecular FunctionISS
GO:0008270zinc ion bindingMolecular FunctionISS
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0048306calcium-dependent protein bindingMolecular FunctionISS
GO:0007613memoryBiological ProcessISS
GO:0007613memoryBiological ProcessIEA
GO:0048168regulation of neuronal synaptic plasticityBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:25742