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Gene Information
Gene ID:257648
Full Name:calcium channel, voltage-dependent, N type, alpha 1B subunit
Organism:Rattus norvegicus (Rat)
Genetic Location:3p13
Physical Location:2852770-3039755 on NC_005102.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 774    Symbol (Name): CACNA1B (calcium channel, voltage-dependent, N type, alpha 1B subunit)
Ortholog Status:The human GeneID 774 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:257648
Fold Change:0.89
P Value:0.022
Note:Fold change is average ratio of AA to ANA.
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_147141.1NP_671482.1NC_005102.2 range: 2852770..3039755, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0005891voltage-gated calcium channel complexCellular ComponentIEA
GO:0005891voltage-gated calcium channel complexCellular ComponentISS
GO:0043198dendritic shaftCellular ComponentIDA (11353727)
GO:0043025cell somaCellular ComponentISS
GO:0043025cell somaCellular ComponentIDA (11353727)
GO:0030425dendriteCellular ComponentISS
GO:0019717synaptosomeCellular ComponentIDA (17562281)
GO:0016021integral to membraneCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentIDA (10864934)
GO:0043679nerve terminalCellular ComponentIDA (16736476)
GO:0005524ATP bindingMolecular FunctionIEA
GO:0008022protein C-terminus bindingMolecular FunctionISS
GO:0005244voltage-gated ion channel activityMolecular FunctionIEA
GO:0005245voltage-gated calcium channel activityMolecular FunctionIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005245voltage-gated calcium channel activityMolecular FunctionIMP (10864934)
GO:0005245voltage-gated calcium channel activityMolecular FunctionISS
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI
GO:0005515protein bindingMolecular FunctionISS
GO:0033574response to testosterone stimulusBiological ProcessIMP (15987667)
GO:0014070response to organic cyclic substanceBiological ProcessIDA (16704976)
GO:0008217regulation of blood pressureBiological ProcessISS
GO:0001956positive regulation of neurotransmitter secretionBiological ProcessIMP (15987667)
GO:0006811ion transportBiological ProcessIEA
GO:0006816calcium ion transportBiological ProcessIEA
GO:0006816calcium ion transportBiological ProcessIMP (10864934)
GO:0006816calcium ion transportBiological ProcessISS
GO:0007269neurotransmitter secretionBiological ProcessISS
GO:0007626locomotory behaviorBiological ProcessISS
GO:0008016regulation of heart contractionBiological ProcessISS
GO:0045471response to ethanolBiological ProcessIEP (16860782)
Other Database Cross Links
NCBI Entrez Gene:257648