ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

POU2F3

Full Name:

POU class 2 homeobox 3

Alias:

Epoc-1|FLJ40063|MGC126698|OCT11|PLA-1|Skn-1a

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

11q23.3

Physical Location:

119616160-119695862 on NC_000011.8

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 18988 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.227115
Note:		"Class II, up-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_014352.2	NP_055167.2	NC_000011.8 range: 119616160..119695862

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (9242494)
GO:0005634	nucleus	Cellular Component	IEA
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (12624109)
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA (9242494)
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	TAS (10473598)
GO:0008544	epidermis development	Biological Process	TAS (10473598)