ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

GAPDH

Full Name:

glyceraldehyde-3-phosphate dehydrogenase

Alias:

G3PD|GAPD|MGC88685

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

12p13

Physical Location:

6513917-6517796 on NC_000012.10

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 14433 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		X01677
Fold Change:		-1.9, -1.6
Note:		Differential expression on the oligonucleotide array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Information

Original ID1:

GAPDH

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D12S99

5434815

Region:		3434815-7434815
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002046.3	NP_002037.2	NC_000012.10 range: 6513917..6517796

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	NAS
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0051287	NAD binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17540579)
GO:0005488	binding	Molecular Function	IEA
GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity	Molecular Function	NAS (3170585\|7030790)
GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity	Molecular Function	IEA
GO:0006096	glycolysis	Biological Process	IEA
GO:0006096	glycolysis	Biological Process	NAS
GO:0008152	metabolic process	Biological Process	IEA
GO:0006006	glucose metabolic process	Biological Process	IEA