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Gene Information
Gene ID:2597
Full Name:glyceraldehyde-3-phosphate dehydrogenase
Organism:Homo sapiens (Human)
Genetic Location:12p13
Physical Location:6513917-6517796 on NC_000012.10
Gene Type:protein-coding
Orthologs:This gene has Mouse: 14433 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:X01677
Fold Change:-1.9, -1.6
Note:Differential expression on the oligonucleotide array (two fold changes are from two case groups)
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.
Gene Information
Original ID1:GAPDH
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Linkage Dataset
MarkerLODP valueLocation (bp)
D12S99  5434815
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_002046.3NP_002037.2NC_000012.10 range: 6513917..6517796
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentNAS
GO:0003824catalytic activityMolecular FunctionIEA
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0051287NAD bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (17540579)
GO:0005488bindingMolecular FunctionIEA
GO:0004365glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activityMolecular FunctionNAS (3170585|7030790)
GO:0004365glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activityMolecular FunctionIEA
GO:0006096glycolysisBiological ProcessIEA
GO:0006096glycolysisBiological ProcessNAS
GO:0008152metabolic processBiological ProcessIEA
GO:0006006glucose metabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:2597
HuGE Navigator:2597