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Gene Information
Gene ID:26035
Symbol:GLCE
Full Name:glucuronic acid epimerase
Alias:HSEPI|KIAA0836
Organism:Homo sapiens (Human)
Chromosome:15
Genetic Location:15q23
Physical Location:67240026-67351597 on NC_000015.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.183006
Note:"Class II, down-regulated gene"
Dataset Information
Name:16292326
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Information
Original ID1:GLCE
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_015554.1NP_056369.1NC_000015.8 range: 67240026..67351597
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000139Golgi membraneCellular ComponentIEA
GO:0005794Golgi apparatusCellular ComponentISS
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0016853isomerase activityMolecular FunctionIEA
GO:0050379UDP-glucuronate 5'-epimerase activityMolecular FunctionIDA (15853773)
GO:0015012heparan sulfate proteoglycan biosynthetic processBiological ProcessISS
GO:0030210heparin biosynthetic processBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:26035
HGNC:17855
Ensembl:ENSG00000138604
MIM:
HPRD:07020
HuGE Navigator:26035
dbSNP:GLCE
GeneCard:GLCE
AceView:GLCE