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Gene Information
Gene ID:2618
Full Name:phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
Organism:Homo sapiens (Human)
Genetic Location:21q22.1|21q22.11
Physical Location:33798138-33836285 on NC_000021.7, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.473648
Note:"Class II, down-regulated gene"
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000819.3NP_000810.1NC_000021.7 range: 33798138..33836285, complement
NM_175085.1NP_780294.1NC_000021.7 range: 33798138..33836285, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005829cytosolCellular ComponentEXP (2147474)
GO:0005737cytoplasmCellular ComponentIEA
GO:0030145manganese ion bindingMolecular FunctionIEA
GO:0016874ligase activityMolecular FunctionIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0008168methyltransferase activityMolecular FunctionIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (17353931)
GO:0003824catalytic activityMolecular FunctionIEA
GO:0004637phosphoribosylamine-glycine ligase activityMolecular FunctionEXP (2147474)
GO:0004637phosphoribosylamine-glycine ligase activityMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0004641phosphoribosylformylglycinamidine cyclo-ligase activityMolecular FunctionEXP (2147474)
GO:0004641phosphoribosylformylglycinamidine cyclo-ligase activityMolecular FunctionIEA
GO:0004644phosphoribosylglycinamide formyltransferase activityMolecular FunctionTAS (2050105)
GO:0006189'de novo' IMP biosynthetic processBiological ProcessIEA
GO:0009113purine base biosynthetic processBiological ProcessIEA
GO:0006164purine nucleotide biosynthetic processBiological ProcessIEA
GO:0009058biosynthetic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:2618
HuGE Navigator:2618