ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

GART

Full Name:

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

21q22.1|21q22.11

Physical Location:

33798138-33836285 on NC_000021.7, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.473648
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005829	cytosol	Cellular Component	EXP (2147474)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0030145	manganese ion binding	Molecular Function	IEA
GO:0016874	ligase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0008168	methyltransferase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17353931)
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0004637	phosphoribosylamine-glycine ligase activity	Molecular Function	EXP (2147474)
GO:0004637	phosphoribosylamine-glycine ligase activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0004641	phosphoribosylformylglycinamidine cyclo-ligase activity	Molecular Function	EXP (2147474)
GO:0004641	phosphoribosylformylglycinamidine cyclo-ligase activity	Molecular Function	IEA
GO:0004644	phosphoribosylglycinamide formyltransferase activity	Molecular Function	TAS (2050105)
GO:0006189	'de novo' IMP biosynthetic process	Biological Process	IEA
GO:0009113	purine base biosynthetic process	Biological Process	IEA
GO:0006164	purine nucleotide biosynthetic process	Biological Process	IEA
GO:0009058	biosynthetic process	Biological Process	IEA