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Gene Information
Gene ID:262
Symbol:AMD1
Full Name:adenosylmethionine decarboxylase 1
Alias:ADOMETDC|AMD|DKFZp313L1234|FLJ26964|SAMDC
Organism:Homo sapiens (Human)
Chromosome:6
Genetic Location:6q21-q22
Physical Location:111302679-111323605 on NC_000006.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.159118
Note:"Class II, down-regulated gene"
Dataset Information
Name:16292326
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Information
Original ID1:AMD1
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001033059.1NP_001028231.1NC_000006.10 range: 111302679..111323605
NM_001634.4NP_001625.2NC_000006.10 range: 111302679..111323605
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005575cellular_componentCellular ComponentND
GO:0004014adenosylmethionine decarboxylase activityMolecular FunctionIEA
GO:0004014adenosylmethionine decarboxylase activityMolecular FunctionTAS (1917972|2460457)
GO:0016829lyase activityMolecular FunctionIEA
GO:0006597spermine biosynthetic processBiological ProcessIEA
GO:0006597spermine biosynthetic processBiological ProcessNAS
GO:0008295spermidine biosynthetic processBiological ProcessIEA
GO:0008295spermidine biosynthetic processBiological ProcessNAS
Other Database Cross Links
NCBI Entrez Gene:262
HGNC:457
Ensembl:ENSG00000123505
MIM:180980
HPRD:01622
HuGE Navigator:262
dbSNP:AMD1
GeneCard:AMD1
AceView:AMD1