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Gene Information
Gene ID:26273
Symbol:FBXO3
Full Name:F-box protein 3
Alias:DKFZp564B092|FBA|FBX3
Organism:Homo sapiens (Human)
Chromosome:11
Genetic Location:11p13
Physical Location:33719065-33752646 on NC_000011.8, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.406787
Note:"Class II, up-regulated gene"
Dataset Information
Name:16292326
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012175.3NP_036307.2NC_000011.8 range: 33719065..33752646, complement
NM_033406.2NP_208385.1NC_000011.8 range: 33719065..33752646, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000151ubiquitin ligase complexCellular ComponentNAS (10531035)
GO:0004842ubiquitin-protein ligase activityMolecular FunctionNAS (10531035)
GO:0004842ubiquitin-protein ligase activityMolecular FunctionTAS (10531035)
GO:0006508proteolysisBiological ProcessTAS (10531035)
GO:0006512ubiquitin cycleBiological ProcessIEA
GO:0016567protein ubiquitinationBiological ProcessNAS (10531035)
Other Database Cross Links
NCBI Entrez Gene:26273
HGNC:13582
Ensembl:ENSG00000110429
MIM:609089
HPRD:16433
HuGE Navigator:26273
dbSNP:FBXO3
GeneCard:FBXO3
AceView:FBXO3