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Gene Information
Gene ID:26406
Symbol:Map3k3
Full Name:mitogen-activated protein kinase kinase kinase 3
Alias:AW548911|KIAA4031|MAPKKK3|Mekk3|mKIAA4031
Organism:Mus musculus (Mouse)
Chromosome:11
Genetic Location:11 E1
Physical Location:105946215-106016759 on NC_000077.5
Gene Type:protein-coding
Human Ortholog:GeneID: 4215    Symbol (Name): MAP3K3 (mitogen-activated protein kinase kinase kinase 3)
Ortholog Status:The human GeneID 4215 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Map3k3
Fold Change:0.63
Note:Significantly regulated by ethanol in cortical neurons
Dataset Information
Name:17295719
Method:Microarray
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_011947.3NP_036077.1NC_000077.5 range: 105946215..106016759
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0016301kinase activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (12912994|14661019)
GO:0004709MAP kinase kinase kinase activityMolecular FunctionIEA
GO:0004674protein serine/threonine kinase activityMolecular FunctionIEA
GO:0004672protein kinase activityMolecular FunctionISS (15001576)
GO:0000287magnesium ion bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0007243protein kinase cascadeBiological ProcessISS (15001576)
GO:0046777protein amino acid autophosphorylationBiological ProcessISS (15001576)
Other Database Cross Links
NCBI Entrez Gene:26406
MGI:
Ensembl:ENSMUSG00000020700
dbSNP:Map3k3
AceView:Map3k3