ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

26417

Symbol:

Mapk3

Full Name:

mitogen-activated protein kinase 3

Alias:

Erk-1|Erk1|Esrk1|Prkm3|p44|p44erk1|p44mapk

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

7 F3|7 61.0 cM

Physical Location:

133903139-133909329 on NC_000073.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5595 Symbol (Name): MAPK3 (mitogen-activated protein kinase 3)

Ortholog Status:

The human GeneID 5595 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Mapk3
Fold Change:		0.65
Note:		Significantly regulated by ethanol in cortical neurons

Gene Information

Original ID1:		Mapk3
Fold Change:		0.73
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011952.2	NP_036082.1	NC_000073.5 range: 133903139..133909329

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IDA (11726647\|12223545)
GO:0005654	nucleoplasm	Cellular Component	EXP (7889942)
GO:0005634	nucleus	Cellular Component	IDA (11726647)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (14636584\|15537391\|15544353)
GO:0004707	MAP kinase activity	Molecular Function	TAS (11684667)
GO:0004707	MAP kinase activity	Molecular Function	IPI (15314156)
GO:0001784	phosphotyrosine binding	Molecular Function	IMP (14636584)
GO:0016301	kinase activity	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	EXP (7889942)
GO:0004672	protein kinase activity	Molecular Function	IDA (15383658)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004707	MAP kinase activity	Molecular Function	IMP (11841548)
GO:0032496	response to lipopolysaccharide	Biological Process	IDA (12872135)
GO:0031663	lipopolysaccharide-mediated signaling pathway	Biological Process	IDA (12872135)
GO:0019233	sensory perception of pain	Biological Process	IMP (11356865)
GO:0043330	response to exogenous dsRNA	Biological Process	IDA (12872135)
GO:0016310	phosphorylation	Biological Process	TAS (12223545)
GO:0009887	organ morphogenesis	Biological Process	IDA (11684667)
GO:0007165	signal transduction	Biological Process	TAS (11684667)
GO:0007049	cell cycle	Biological Process	IEA
GO:0006974	response to DNA damage stimulus	Biological Process	IDA (15383658)
GO:0006468	protein amino acid phosphorylation	Biological Process	IDA (11841548\|15383658)
GO:0051216	cartilage development	Biological Process	IDA (17644814)