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Gene Information
Gene ID:5595
Symbol:MAPK3
Full Name:mitogen-activated protein kinase 3
Alias:ERK1|HS44KDAP|HUMKER1A|MGC20180|P44ERK1|P44MAPK|PRKM3
Organism:Homo sapiens (Human)
Chromosome:16
Genetic Location:16p11.2
Physical Location:30032926-30042130 on NC_000016.8, complement
Gene Type:protein-coding
Orthologs:This gene has Mouse: 26417 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:MAPK3
Dataset Information
Name:18477577
Method:Addiction array gene list
Publication:Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001040056.1NP_001035145.1NC_000016.8 range: 30032926..30042130, complement
NM_001109891.1NP_001103361.1NC_000016.8 range: 30032926..30042130, complement
NM_002746.2NP_002737.2NC_000016.8 range: 30032926..30042130, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005829cytosolCellular ComponentEXP (7739560)
GO:0005654nucleoplasmCellular ComponentEXP (9687510|11741541|16456541|16626623|17322878)
GO:0005575cellular_componentCellular ComponentND
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionNAS
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (9792677|15616583|16291755)
GO:0004707MAP kinase activityMolecular FunctionNAS (7687743)
GO:0004672protein kinase activityMolecular FunctionIEA
GO:0004674protein serine/threonine kinase activityMolecular FunctionEXP (16626623)
GO:0004674protein serine/threonine kinase activityMolecular FunctionIEA
GO:0004707MAP kinase activityMolecular FunctionEXP (11741541)
GO:0004707MAP kinase activityMolecular FunctionIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0006468protein amino acid phosphorylationBiological ProcessIDA (7687743)
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0007049cell cycleBiological ProcessIEA
GO:0007265Ras protein signal transductionBiological ProcessEXP (11520933)
Other Database Cross Links
NCBI Entrez Gene:5595
HGNC:6877
Ensembl:ENSG00000102882
MIM:601795
HPRD:03479
HuGE Navigator:5595
dbSNP:MAPK3
GeneCard:MAPK3
AceView:MAPK3