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Gene Information
Gene ID:27150
Symbol:Kcnh3
Full Name:potassium voltage-gated channel, subfamily H (eag-related), member 3
Alias:Bec1|Elk2
Organism:Rattus norvegicus (Rat)
Chromosome:7
Genetic Location:7q36
Physical Location:137984617-138002552 on NC_005106.2
Gene Type:protein-coding
Human Ortholog:GeneID: 23416    Symbol (Name): KCNH3 (potassium voltage-gated channel, subfamily H (eag-related), member 3)
Ortholog Status:The human GeneID 23416 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Kcnh3
Fold Change:1.13
P Value:0.008
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_017108.1NP_058804.1NC_005106.2 range: 137984617..138002552
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0000155two-component sensor activityMolecular FunctionIEA
GO:0030955potassium ion bindingMolecular FunctionIEA
GO:0005249voltage-gated potassium channel activityMolecular FunctionIEA
GO:0005244voltage-gated ion channel activityMolecular FunctionIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0006813potassium ion transportBiological ProcessIEA
GO:0000160two-component signal transduction system (phosphorelay)Biological ProcessIEA
GO:0006811ion transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:27150
RGD:71070
Ensembl:ENSRNOG00000032075
dbSNP:Kcnh3