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Gene Information
Gene ID:2742
Symbol:GLRA2
Full Name:glycine receptor, alpha 2
Alias:GLR
Organism:Homo sapiens (Human)
Chromosome:X
Genetic Location:Xp22.1-p21.3
Physical Location:14457570-14659854 on NC_000023.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:GLRA2
Dataset Information
Name:18477577
Method:Addiction array gene list
Publication:Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.
Gene Information
Original ID1:GLRA2
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_002063.3NP_002054.1NC_000023.9 range: 14457570..14659854
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0045211postsynaptic membraneCellular ComponentIEA
GO:0045202synapseCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentIEA
GO:0005887integral to plasma membraneCellular ComponentNAS (2155780)
GO:0030054cell junctionCellular ComponentIEA
GO:0031404chloride ion bindingMolecular FunctionIEA
GO:0030594neurotransmitter receptor activityMolecular FunctionIEA
GO:0016934extracellular-glycine-gated chloride channel activityMolecular FunctionIDA (2155780)
GO:0016594glycine bindingMolecular FunctionIDA (2155780)
GO:0004890GABA-A receptor activityMolecular FunctionIEA
GO:0005230extracellular ligand-gated ion channel activityMolecular FunctionIEA
GO:0005216ion channel activityMolecular FunctionIEA
GO:0004891glycine-inhibited chloride channel activityMolecular FunctionTAS (2155780)
GO:0006821chloride transportBiological ProcessIEA
GO:0006811ion transportBiological ProcessIDA (2155780)
GO:0007218neuropeptide signaling pathwayBiological ProcessIDA (2155780)
Other Database Cross Links
NCBI Entrez Gene:2742
HGNC:4327
Ensembl:ENSG00000101958
MIM:305990
HPRD:02379
HuGE Navigator:2742
dbSNP:GLRA2
GeneCard:GLRA2
AceView:GLRA2