ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

GLRB

Full Name:

glycine receptor, beta

Organism:

Homo sapiens (Human)

Chromosome:

4

Genetic Location:

4q31.3

Physical Location:

158216787-158312303 on NC_000004.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

GLRB

Dataset Information

Name:		18477577
Method:		Addiction array gene list
Publication:		Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:		To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000824.3	NP_000815.1	NC_000004.10 range: 158216787..158312303

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0045211	postsynaptic membrane	Cellular Component	IEA
GO:0030054	cell junction	Cellular Component	IEA
GO:0045202	synapse	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	NAS (8717357)
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IPI (11929858\|15215304)
GO:0005230	extracellular ligand-gated ion channel activity	Molecular Function	IEA
GO:0031404	chloride ion binding	Molecular Function	IEA
GO:0030594	neurotransmitter receptor activity	Molecular Function	IEA
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0016934	extracellular-glycine-gated chloride channel activity	Molecular Function	IDA (8717357)
GO:0016594	glycine binding	Molecular Function	IMP (15748848)
GO:0007399	nervous system development	Biological Process	IMP (11929858)
GO:0007268	synaptic transmission	Biological Process	IMP (11929858)
GO:0007218	neuropeptide signaling pathway	Biological Process	IDA (8717357)
GO:0006821	chloride transport	Biological Process	IEA
GO:0006811	ion transport	Biological Process	IDA (8717357)
GO:0001964	startle response	Biological Process	IMP (11929858)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000109738

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: